論文
PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating
PRDM1.
Yuichiro Nakata, Shion Nagasawa, Yasuyuki Sera, Norimasa Yamasaki, Akinori Kanai, Kohei Kobatake, Takeshi Ueda, Miho Koizumi, Ichiro Manabe, Osamu Kaminuma, Hiroaki Honda.
Sci Rep, 2024 Aug 3;14(1):17987
From the genesis to the present: The evolution of sublingual immunotherapy
for cedar pollinosis.
Minoru Gotoh, Osamu Kaminuma, Kimihiro Okubo.
Allergol Int, 2024 Jul 22;S1323-8930(24)00074-1.
Structure-activity relationship studies of pyrogallol as a calcineurin/NFAT
signaling suppressor.
Hiroyuki Mizuguchi, Tomohira Ito, Kohei Nishida, Tomoharu Wakugawa, Tomohiro
Nakano, Akie Tanabe, Tomokazu Watano, Noriko Kitamura, Osamu Kaminuma, Katsunori Kimura, Tatsuya Ishida, Atsushi Matsunaga, Kazumi Ohta, Rina
Shimono, Haruo Kutsuna, Taiei Yasuda, Masami Yabumoto, Yoshiaki Kitamura,
Noriaki Takeda, Hiroyuki Fukui.
J Pharmacol Sci, 2024 Jul 22;155(4):140-147.
α7 nicotinic acetylcholine receptor agonist attenuates allergen-induced
immediate nasal response in murine model of allergic rhinitis.
Shuhei Yamashita, Kento Miura, Anna Matsuura, Norimasa Yamasaki, Naoto Uda, Sawako Ogata, NaohisaHosomi, Shotaro Nakajima, Noriko Kitamura, Minoru Gotoh, Akio Mori, Osamu Kaminuma.
Journal of Veterinary Medical Science, 2024 Jul 4;86(7):824-827.
Involvement of CCR5 on interstitial macrophages in the development of lung
fibrosis in severe asthma.
Masaya Matsuda, Hayato Shimora, Yukino Nagatani, Keitaro Nishikawa, Itomi
Takamori, Tenta Haguchi, Kazuyuki Kitatani, Osamu Kaminuma, Takeshi Nabe.
International Immunopharmacology, 2024 Jun 30;135:112331.
Nesprin1 deficiency is associated with poor prognosis of renal cell carcinoma
and resistance to sunitinib treatment.
Takafumi Fukushima, Kohei Kobatake, Kento Miura, Kenshiro Takemoto, Ryoken Yamanaka, Ryo Tasaka, Yuki Kohada, Shunsuke Miyamoto, Yohei Sekino, Hiroyuki Kitano, Keisuke Goto, Kenichiro
Ikeda, Akihiro Goriki, Keisuke Hieda, Osamu Kaminuma, Nobuyuki Hinata.
Oncology, 2024 Mar 05;102 (10): 868–879.
Intracytoplasmic sperm injection induces transgenerational abnormalities
in mice.
Mito Kanatsu-Shinohara, Yusuke Shiromoto, Narumi Ogonuki, Kimiko Inoue,
Satoko Hattori, Kento Miura, Naomi Watanabe, Ayumi Hasegawa,Keiji Mochida, Takuya Yamamoto, Tsuyoshi
Miyakawa, Atsuo Ogura,Takashi Shinohara
J Clin Inves, 2023 Nov 15;133(22):e170140.
Generation of reporter mice for detecting the transcriptional activity
of nuclear factor of activated T cells.
Norimasa Yamasaki, Kento Miura, Sawako Ogata, Shuka Miura, Arikuni Uchimura, Yasunari Satoh, Masaaki Toshishige, Naohisa Hosomi,
Maribet Gamboa, Noriko Kitamura, Osamu Kaminuma.
Experimental Animals, 2023 Nov 9;72(4):454-459.
JPH203, a LAT1 inhibitor, alleviates steroid-resistant murine airway inflammation
mediated by Th17 cells.
Keitaro Hayashi, Mayumi Saeki, Kento Miura, Norimasa Yamasaki, Masaya Matsuda, Hayato Shimora, Takeshi Nabe, Yasuo Shimizu, Tomoe Fujita,
Hitoshi Endou, Osamu Kaminuma.
Allergy, 2023 Oct;78(10):2780-2783.
Evolutionary mechanisms underlying the diversification of nuclear factor
of activated T cells across vertebrates.
Maribet Gamboa, Noriko Kitamura, Kento Miura, Satoko Noda, Osamu Kaminuma.
Scientific Reports, 2023;13:6468.
★プレスリリースされました
脊椎動物の免疫システムにおける進化のメカニズムが明らかに
Re-evaluation of over-the-counter histamine H1-receptor antagonists based
on their effects on murine models of allergen-induced nasal hyperresponsiveness.
Naoto Uda, Sawako Ogata, Norimasa Yamasaki, Shuka Miura, Naohisa Hosomi, Akio Mori, Minoru Gotoh, Kento Miura, Osamu Kaminuma.
J Pharmacol Sci, 2022 Dec;150(4):275-278.
Suppressive Effect of Lactococcus lactis subsp. cremoris YRC3780 on a Murine
Model of Japanese Cedar Pollinosis.
Kenji Uchida, Kenichi Iida, Ikumi Fujioka, Satoshi Hachimura, Osamu Kaminuma.
Pathogens, 2022, 11(11):1347.
BACH1 promotes clear cell renal cell carcinoma progression via upregulating
oxidative stress-related tumorigenicity.
Takemoto K, Kobatake K, Miura K, Fukushima T, Babasaki T, Miyamoto S, Sekino Y, Kitano H, Goto K, Ikeda
K, Hieda K, Hayashi T, Hinata N, Kaminuma O.
Cancer Sci, 2023 Feb;114(2):436-448.
DDX41 expression is associated with tumor necrosis in clear cell renal
cell carcinoma and in cooperation with VHL loss leads to worse prognosis.
Kobatake K, Ikeda K, Nakata Y, Yamasaki N, Kanai A, Sekino Y, Takemoto K, Fukushima T, Babasaki T, Kitano H, Goto K, Hayashi T, Sentani K, Teishima
J, Kaminuma O, Hinata N.
Urologic Oncology, 2022;40:456.e9-456.e18.
Th17-dependent nasal hyperresponsiveness is mitigated by steroid treatment.
Ueda S, Miura K, Kawasaki H, Ogata S, Yamasaki N, Miura S, Mori A, Kaminuma O.
Biomolecules, 2022;12:674.
Regulation of Th2 responses by Lactococcus lactis subsp. Cremoris YRC3780
alleviates DNCB-induced atopic dermatitis in the mouse.
Wang R, Nakajima-Adachi H, Wang Y, Zhou Y, Gu W, Hiraide E, Morinaga M,
Nakagawa R, Nakamura S, Takano T, Li X, Saeki M, Kaminuma O, Hiroi T, Uchida K, Motoshima H, Tanokura M, Miyakawa T, Hachimura S.
J Funct Foods, 2022;94,105091.
Noncanonical imprinting sustains embryonic development and restrains placental
overgrowth.
Matoba S, Kozuka C, Miura K, Inoue K, Kumon M, Hayashi R, Ohhata T, Ogura A, Inoue A.
Genes Dev.2022 Apr 1;36(7-8):483-494.
Expression and function of nicotinic acetylcholine receptors in inducedregulatory
T cells.
Nakata Y, Miura K, Yamasaki N, Ogata S, Miura S, Hosomi N, Kaminuma O.
Int J Mol Sci, 2022;23:1779,.
Highly rigid H3.1/H3.2-H3K9me3 domains set a barrier for cell fate reprogramming
in trophoblast stem cells.
Hada M, Miura H, Tanigawa A, Matoba S, Inoue K, Ogonuki N, Hirose M, Watanabe
N, Nakato R, Fujiki K, Hasegawa A, Sakashita A, Okae H,
Miura K, Shikata D, Arima T, Shirahige K, Hiratani I, Ogura A.
Genes Dev.2022 Jan 1;36(1-2):84-102.
L-type amino acid transporter 1 inhibitor suppresses murine Th2 cell-mediated
bronchial hyperresponsiveness independently of eosinophil accumulation
Daiki Ito, Kento Miura, Mayumi Saeki, Norimasa Yamasaki, Sawako Ogata, Teidai Koyama, Takachika Hiroi, Akio Mori, Hitoshi Endou, Keitaro Hayashi, and Osamu Kaminuma
Asia Pac Allergy. 2021 Jul 19;11:e33.
Suppressive effect of dexamethasone on murine Th9 cell-mediated nasal eosinophilic
inflammation
Teidai Koyama, Kento Miura, Norimasa Yamasaki, Sawako Ogata, Daiki Ito, Mayumi Saeki, Takachika Hiroi, Akio Mori, and Osamu Kaminuma
Asia Pac Allergy. 2021 Jul 7;11:e25
Early Crypt Formation Defects in the Uterine Epithelia of Sox17 Heterozygous
Mice
Yoshikazu Hirate, Kana Hayakawa, Yuki Nakano, Shiori Kumazawa, Kento Miura, Yoshiakira Kanai, Masami Kanai-Azuma
Sex Dev.2021 Mar 9;1-11.
Epicutaneous allergen administration without antigen delivery device induces
local T cell response and alleviates food allergic enteropathy
Mamiko Morinaga, Haruyo Nakajima-Adachi, Erika Hiraide, Noriko Kitamura,
Osamu Kaminuma, Takachika Hiroi, Katsuyo Ohashi-Doi, Satoshi Hachimura
Allergol Int.2020 Oct;69(4):622-625.
Generation of chimeric mice with spermatozoa fully derived from embryonic
stem cells using a triple-target CRISPR method for Nanos3
Kento Miura, Shogo Matoba, Michiko Hirose, Atsuo Ogura
Biol Reprod. 2021 Jan 4;104(1):223-233.
★理化学研究所バイオリソース研究センターの"BRC Current Technology"で紹介されました
1世代でES細胞由来の精子のみを持つキメラマウスを作出 ～コンディショナルノックアウトマウスを用いない致死遺伝子の機能解析～
★Biology of Reproductionの"COMMENTARY"で紹介されました
Conditional surrender in one generation: determining the reproductive roles
of mouse embryo lethal genes by embryo complementation
L-type amino acid transporter 1 (LAT1)-specific inhibitor is effective
against T cell-mediated nasal hyperresponsiveness
Osamu Kaminuma, Tomoe Nishimura, Mayumi Saeki, Norimasa Yamasaki, Sawako Ogata, Tomoe Fujita, Hitoshi Endou, Keitaro Hayashi
Allergol Int. 2020 Jul;69(3):455-458.
Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement
of cloned mouse placentas
Kimiko Inoue, Narumi Ogonuki, Satoshi Kamimura, Hiroki Inoue, Shogo Matoba,
Michiko Hirose, Arata Honda, Kento Miura, Masashi Hada, Ayumi Hasegawa, Naomi Watanabe, Yukiko Dodo, Keiji Mochida,
Atsuo Ogura
Nat Commun. 2020 May 1;11(1):2150.
Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated
nasal eosinophilic inflammation
Tomoe Nishimura, Osamu Kaminuma, Mayumi Saeki, Noriko Kitamura, Akio Mori, Takachika Hiroi
Asia Pac Allergy.2020 Apr 27;10(2):e18.
Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage
Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction
Kohei Kobatake, Ken-Ichiro Ikeda, Yuichiro Nakata, Norimasa Yamasaki, Takeshi Ueda, Akinori Kanai, Kazuhiro Sentani, Yasuyuki Sera, Tetsutaro
Hayashi, Miho Koizumi, Yoshihiko Miyakawa, Toshiya Inaba, Yusuke Sotomaru,
Osamu Kaminuma, Tatsuo Ichinohe, Zen-Ichiro Honda, Wataru Yasui, Shigeo Horie, Peter
C Black, Akio Matsubara, Hiroaki Honda
Clin Cancer Res. 2020 Apr 15;26(8):2065-2079.
Association of Basophil-Expressing Genes with Effectiveness of Sublingual
Immunotherapy
Minoru Gotoh, Osamu Kaminuma, Akihiro Nakaya, Mayumi Saeki, Tomoe Nishimura, Noriko Kitamura, Takachika
Hiroi, Kimihiro Okubo
J Nippon Med Sch. 2020 Mar 11;87(1):49-52.
Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications
of myeloid-derived suppressor cells and NO production
Masashi Tachibana, Nobumasa Watanabe, Yuzo Koda, Yukako Oya, Osamu Kaminuma, Kazufumi Katayama, Zifei Fan, Fuminori Sakurai, Kenji Kawabata, Takachika
Hiroi, Hiroyuki Mizuguchi
Int Immunol.2020 Mar 7;32(3):187-201
Identification of novel interacting regions involving calcineurin and nuclear
factor of activated T cells
Noriko Kitamura, Mayumi Shindo, Jun Ohtsuka, Akira Nakamura, Masaru Tanokura,
Takachika Hiroi, Osamu Kaminuma
FASEB J. 2020 Feb;34(2):3197-3208.
LAT1-specific inhibitor is effective against T cell-mediated allergic skin
inflammation
Keitaro Hayashi, Osamu Kaminuma, Tomoe Nishimura, Mayumi Saeki, Kunie Matsuoka, Takachika Hiroi, Promsuk
Jutabha, Yohei Iwata, Kazumitsu Sugiura, Takayoshi Owada, Kazuhiro Kurasawa,
Isao Okayasu, Motoshi Ouchi, Tomoe Fujita, Yoshikatsu Kanai, Hitoshi Endou,
Naohiko Anzai
Allergy. 2020 Feb;75(2):463-467.
Identification of pyrogallol from Awa-tea as an anti-allergic compound
that suppresses nasal symptoms and IL-9 gene expression
Tomohiro Nakano, Mitsuhiro Ikeda, Tomoharu Wakugawa, Yoshiki Kashiwada,
Osamu Kaminuma, Noriko Kitamura, Masam Yabumoto, Hiromichi Fujino, Yoshiaki Kitamura,
Hiroyuki Fukui, Noriaki Takeda, Hiroyuki Mizuguchi
J Med Invest. 2020;67(3.4):289-297.
Thrombospondin 1-mediated suppression of mast cell degranulation is involved
in the efficacy of sublingual immunotherapy
Osamu Kaminuma, Noriko Kitamura, Minoru Gotoh, Mayumi Shindo, Nobumasa Watanabe, Mayumi
Saeki, Tomoe Nishimura, Akio Mori, Soichi Nemoto, Hideki Tatsumi, Kimihiro
Okubo, Takachika Hiroi
Allergol Int.2019 Sep;68S:S9-S10.
Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness
in a murine model of allergic rhinitis
Tomoe Nishimura, Osamu Kaminuma, Mayumi Saeki, Noriko Kitamura, Minoru Gotoh, Akio Mori, Takachika Hiroi
Allergol Int.2018 Sep;67S:S25-S31.
Microarray-Based Multivariate Analysis of the Effectiveness of Sublingual
Immunotherapy for Cedar Pollinosis
Minoru Gotoh, Osamu Kaminuma, Takachika Hiroi, Kimihiro Okubo
Allergy Asthma Immunol Res.2018 Sep;10(5):562-569.
Involvement of taste receptors in the effectiveness of sublingual immunotherapy
Minoru Gotoh, Osamu Kaminuma, Akihiro Nakaya, Kazufumi Katayama, Nobumasa Watanabe, Mayumi Saeki, Tomoe
Nishimura, Noriko Kitamura, Kimihiro Okubo, Takachika Hiroi
Allergol Int.2018 Jul;67(3):421-424.
Contribution of neuraminidase 3 to the differentiation of induced regulatory
T cells
Osamu Kaminuma, Shigeki Katoh, Taeko Miyagi, Nobumasa Watanabe, Noriko Kitamura, Tomoe
Nishimura, Mayumi Saeki, Akio Mori, Takachika Hiroi
Genes Cells. 2018 Feb;23(2):112-116.
Downregulation of NFAT3 Due to Lack of T-Box Transcription Factor TBX5
Is Crucial for Cytokine Expression in T Cells
Osamu Kaminuma, Noriko Kitamura, Yasumasa Nishito, Soichi Nemoto, Hideki Tatsumi, Akio
Mori, Takachika Hiroi
J Immunol. 2018 Jan 1;200(1):92-100
T-Helper Type 2 Cells Direct Antigen-Induced Eosinophilic Skin Inflammation
in Mice
Osamu Kaminuma, Tomoe Nishimura, Noriko Kitamura, Mayumi Saeki, Takachika Hiroi, Akio
Mori
Allergy Asthma Immunol Res.2018 Jan;10(1):77-82.
Serum Cytokine Interactions Are Implicated in the Mechanism of Action of
Sublingual Immunotherapy for Japanese Cedar Pollinosis
Kenichi Shimada, Minoru Gotoh, Kimihiro Okubo, Takachika Hiroi, Osamu Kaminuma, Akihiro Nakaya
J Nippon Med Sch.2018;85(5):250-258.
Hyper-reactive cloned mice generated by direct nuclear transfer of antigen-specific
CD4 + T cells
Osamu Kaminuma, Kazufumi Katayama, Kimiko Inoue, Mayumi Saeki, Tomoe Nishimura, Noriko
Kitamura, Yusuke Shimo, Soichi Tofukuji, Satoru Ishida, Narumi Ogonuki,
Satoshi Kamimura, Mami Oikawa, Shigeki Katoh, Akio Mori, Michitaka Shichijo,
Takachika Hiroi, Atsuo Ogura
EMBO Rep. 2017 Jun;18(6):885-893.
総説
LAT1:アレルギー性鼻炎治療における新たな標的分子.
神沼 修、林 啓太朗、後藤 穣
アレルギーの臨床, 2024;729:33-36.
アレルゲン応答の免疫学的機構．特集：アレルゲン免疫療法の有用性とその実際．
神沼 修．
Progress in Medicin, 2023;43:193-197.
L-type amino acid transporter 1（LAT1）特異的阻害薬による難治性気管支喘息治療の可能性．
林 啓太朗、神沼 修．
日本薬理学雑誌, 2022;157:305-309.
重症喘息のステロイド抵抗性とその制御．
森 晶夫、神山 智、大友 暁美、山口 美也子、組谷 智恵美、岩本 圭右、矢野 光一、藤田 教寛、岩田 真紀、永山 貴紗子、劉 楷、中村 祐人、濱田 祐斗、渡井
健太郎、上出 庸介、福富 友馬、関谷 潔史、松元 幸一郎、谷口 安、小林 信之、大友 隆之、神沼 修．
日本薬理学雑誌, 2022;157:293-298.
舌下免疫療法のメカニズム解明－臨床研究からわかったこと－．
神沼 修、後藤 穣．
アロス エルゴン, 2022;2:687-695.
アレルゲン免疫療法の好塩基球を介した奏功機構．
神沼 修、後藤 穣．
アレルギーの臨床, 2022;42:52-55.
Therapeutic potential for intractable asthma by targeting L-type amino
acid transporter 1 .
Hayashi K, Kaminuma O.
Biomolecules, 2022;12:553.
Progress of genome editing technology and developmental biology useful
for radiation research
Kento Miura, Atsuo Ogura, Kohei Kobatake, Hiroaki Honda, Osamu Kaminuma
J Radiat Res. 2021 May 5;62(Supplement_1):i53-i63.
Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development
Noriko Kitamura, Osamu Kaminuma
Int. J. Mol. Sci.2021; 22(5), 2725
Sublingual Immunotherapy: How Sublingual Allergen Administration Heals
Allergic Diseases; Current Perspective about the Mode of Action
Minoru Gotoh, Osamu Kaminuma
Pathogens. 2021;10(2), 147
T細胞依存的アレルギー性炎症の臓器・サブセット特異的な薬剤応答性
神沼 修,三浦 健人, 林 啓太朗, 佐伯 真弓, 廣井 隆親, 森 晶夫
アレルギーの臨床．2021 Jan;41(2):80-8
Role of CD4+ T Cells in Allergic Airway Diseases: Learning from Murine
Models
Kento Miura, Kimiko Inoue, Atsuo Ogura,Osamu Kaminuma
Int J Mol Sci.2020 Oct 11;21(20):7480.
皮膚アレルギー研究に役立つ新しいマウスモデル
神沼 修,吉川 日出雄, 森 晶夫
臨床免疫・アレルギー科.2020 May;73(5):506-512
T Cell-Mediated Nasal Hyperresponsiveness in Allergic Rhinitis
Osamu Kaminuma, Tomoe Nishimura, Mayumi Saeki, Akio Mori, Takachika Hiroi
Biol Pharm Bull.2020;43(1):36-40.
転写因子NFATファミリーにおけるアイソフォーム選択的制御の意義と可能性
北村 紀子, 神沼 修
Journal of Japanese Biochemical Society.2020; 92(6):783-790
マウスTh9細胞移入喘息モデルの解析からみえてきた新たな気道過敏性亢進機構
佐伯 真弓, 神沼 修, 廣井 隆親
日本薬理学雑誌.2020;155 (6)
Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial
Hyperresponsiveness
Mayumi Saeki, Tomoe Nishimura, Noriko Kitamura, Takachika Hiroi, Akio Mori,
Osamu Kaminuma
Int J Mol Sci.2019 Jun 18;20(12):2980.
統合比較解析で見えてきたアレルゲン免疫療法の作用メカニズム
神沼 修, 後藤 穣, 大久保 公裕, 中谷 明弘, 廣井 隆親
日本薬理学雑誌.2019;154 (1):23-27
鼻粘膜過敏性によるアレルギー性鼻炎病態評価の重要性
神沼 修, 西村 友枝, 廣井 隆親, 森 晶夫
アレルギーの臨床. 2018 Sep;38: 884-889
T細胞依存性マウス気管支喘息モデルを用いた基礎研究からの提言
アレルギーの臨床.2018;38:461-466
T細胞核移植クローンマウス研究から見えてきた新たな喘息治療の方向性
神沼 修, 形山 和史, 井上 貴美子, 小倉 淳郎, 廣井 隆親, 森 晶夫
アレルギーの臨床.2018 Apr;38:365-370
特集 花粉症の基礎と臨床 アップデートⅠ．花粉症における鼻粘膜過敏性亢進の発症機構
神沼修, 西村友枝 , 廣井隆親
アレルギー・免疫. 2018 Jan;25(2)